Prof. J. Jeyakanthan has been concentrating on three major thrust areas such as Structural Biology, Computer Aided Drug Design and Bio-Computing. He has 23 years of Research experience and been mainly focusing to unravel the Structural and Functional aspects of important proteins from model organisms Thermus thermophilus HB8, Pyrococcus horikoshii OT3 and Aquifex aeolicus VF5 that remain unanswered. Additionally, enzymes that control purine and pyrimidine levels are also been studied. Furthermore, identification of drug leads through computational screening against life-threatening diseases such as TB, Filariasis, Cancer, Diabetes, Chikunguinaya, Dengue, Malaria and nosocomial infection. The identified potential leads will be evaluated by in vitro studies.